Parkinson’s Disease: Manchester paves the way for new treatments and diagnostics

Author: Jo Sharpe Parkinson’s disease is a devastating illness that is progressive, incurable, and notoriously difficult to diagnose. It is caused by the death of dopaminergic neurons in the substantia nigra - an area of the midbrain. Defective dopamine signalling results in severe motor defects in patients, which manifest as tremors, muscle cramps and lethargy, in … Continue reading Parkinson’s Disease: Manchester paves the way for new treatments and diagnostics

Research spotlight at Manchester: 3D Bioprinting

A considerable challenge for researchers that investigate human disease is to be able to accurately recreate the disease outside of the human body. Disease investigation in vitro, (or ‘in a dish’) is described as ‘disease modelling’ and generally involves isolating or generating diseased cells before subjecting them to various conditions. Disease models are an invaluable … Continue reading Research spotlight at Manchester: 3D Bioprinting

How far are we from growing our own organs in the lab?

Author: Paul Humphreys One of the greatest promises of tissue engineering and regenerative medicine is the ability to generate functional organs for transplantation. Pluripotent stem cells (PSCs), derived from IVF embryos or reprogrammed adult cells, have the capacity to form any cell type and therefore may potentially provide the source of cells required for tissue … Continue reading How far are we from growing our own organs in the lab?